Active Purified Enzymes

NOVOCIB produces active nucleoside kinases and other nucleotide metabolism enzymes. This portfolio of enzymes represents a unique range of powerful tools for Drug Discovery and research in the field of nucleoside and nucleotide metabolism.

Purine Metabolism Enzymes

IMPDH
Inosine Monophosphate Dehydrogenase (EC 1.1.1.205) Human Type II, recombinant, expressed in E.coli Bacterial (Staphylococcus aureus) recombinant, expressed in E.coli
PNP
Purine Nucleoside Phosphorylase (EC 2.4.2.1) Human recombinant, expressed in E.coli
HGPRT
Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) Human recombinant, expressed in E.coli

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Nucleoside Kinases

ADK
Adenosine Kinase (EC 2.7.1.20) Human, recombinant, expressed in E.coli
dCK
Deoxycytidine Kinase (EC 2.7.1.74) Human recombinant, expressed in E.coli
CMK
UMP-CMP Kinase (EC 2.7.4.14) Human recombinant, expressed in E.coli
cN-II
Cytosolic 5'-nucleotidase II (EC 3.1.3.5) Human recombinant, expressed in E.coli

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Bacterial Bioluminescence Enzymes

Bacterial Luciferase
(EC 1.14.14.3) Bacterial, produced from a selected strain of Photobacterium phosphoreum
FMN Reductase
(EC 1.5.1.29) Bacterial recombinant, E.coli

Bacterial bioluminescence consists in a ligh-emitting reaction where a long-chain aliphatic aldehyde is oxidized in the presence of molecular oxygen and reduced flavin mononucleotide (FMNH2). This reaction is catalyzed by bacterial luciferase.

NOVOCIB offers a highly pure bacterial luciferase from Photobacterium phosphoreum and a recombinant FMN-Reductase which, when coupled to bacterial luciferase in vitro, is able to significantly increase the sensitivity and allow a better control of signal intensity and duration.

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